TMPRSS2 As an Influential Human Gene for COVID-19

: In December 2019, the new virus, COVID-19, emerged and led to a pandemic respiratory acute disease. Almost all countries have experienced different rates of morbidity mortality. These differences can be attributed factors such as diagnostic test capacity for COVID-19 health system efficiency. Besides between related management, patients represent diverse range clinical symptoms, from outpatient admitted intensive care unit (ICU) due severity symptoms. To gain deeper insights into disparities in presentations, epidemiological studies reported risk old age, male sex, underlying chronic diseases diabetes, inflammatory cardiovascular diseases, which bearing on susceptibility COVID-19. addition these factors, molecular mechanism involved virus entry process has been under investigation. Apart well-known protein called ACE2 (angiotensin-converting enzyme 2), plays receptor role another essential this pathway is TMPRSS2 (transmembrane protease, serine 2). This protease crucial effective membrane integration target cell. affect infection mortality rate Thus, it seems that understanding help better management by designing inhibitors drugs. Given variants gene, are associated with people exposed severe forms disease identified before deterioration adopt appropriate therapeutic approaches. Therefore, study focused levels interactions severity.